Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureRuifu Chemical Supply Olmesartan Medoxomil Intermediates With High Quality: 4,5-Dimethyl-1,3-Dioxol-2-One (DMDO) CAS 37830-90-3 4-Chloromethyl-5-Methyl-1,3-Dioxol-2-One (DMDO-Cl) CAS 80841-78-7 Ethyl 4-(1-Hydroxy-1-Methylethyl)-2-Propyl-Imidazole-5-Carboxylate CAS 144689-93-0 Diethyl 2-Propyl-1H-Imidazole-4,5-Dicarboxylate CAS 144689-94-1 Trityl Olmesartan Ethyl Ester CAS 144690-33-5 Trityl Olmesartan Acid CAS 761404-85-7 N2-Trityl Olmesartan Acid CAS 752179-89-8 Trityl Olmesartan Medoxomil CAS 144690-92-6 Olmesartan Medoxomil CAS 144689-63-4| Item | Specifications |
| Appearance | White to Almost White Cyrstalline Powder |
| Identification | IR, HPLC, UV: Must Conform to Reference Standard |
| Purity / Analysis Method | >99.5% (HPLC on the Anhydrous and Solvent-Free Basis) |
| Loss on Drying | <0.50% |
| Residue on Ignition | <0.10% |
| Related Substances | |
| Olmesartan RRT 0.2 | <0.50% |
| Olmesartan Medoxoil Related Compound A. RRT 0.7 | <0.20% |
| Olefinic Impurity RRT 1.6 | <0.50% |
| N-Alkyl Impurity RRT 3.4 | <0.10% |
| Any Other Impurity | <0.10% |
| Total Impurities | <0.50% |
| Heavy Metals (as Pb) | <10ppm |
| pH of Solution (2%, W/V) | 4.5 to 6.5 |
| Test Standard | Enterprise Standard; USP Standard |
| Usage | API |
Description:
Specifications:
Package & Storage:
| Chemical Name | Olmesartan Medoxomil |
| Synonyms | 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester; CS-866 |
| CAS Number | 144689-63-4 |
| CAT Number | RF-PI1730 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C29H30N6O6 |
| Molecular Weight | 558.60 |
| Melting Point | 180℃ (dec.) |
| Water Solubility | Insoluble in Water; Slightly Soluble in DMSO |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
Olmesartan Medoxomil (CS-866) (CAS: 144689-63-4) is a potent and selective angiotensin II type 1 (AT(1)) receptor antagonist with IC50 of 66.2 μM., used in the treatment of high blood pressure. Used as an anti-hypertensive. Olmesartan works by blocking the binding of angiotensin II to the AT1 receptors in vascular muscle. By blocking the binding rather than the synthesis of angiotensin II, Olmesartan inhibits the negative regulatory feedback on renin secretion. Olmesartan Medoxomil is a pro-drug that is de-esterified to the active metabolite, olmesartan. Olmesartan Medoxomil was launched in the US as Benicar, an orally administered treatment for hypertension.
